UNC13D CLIA Kit for Human(Homo sapiens) | EIAab.comUNC13D CLIA Kit for Human(Homo sapiens)

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UNC13D (Gene name),

Protein unc-13 homolog D (Protein name ), UN13D_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UNC13D;

Protein name:

Protein unc-13 homolog D;

Alternative:

Munc13-4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with DOC2A (By similarity). Interacts with RAB27A.

Function:

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Late endosome Recycling endosome Lysosome Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.

Protein Attributes:

Sequence length:

1090

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

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550:

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650:

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850:

900:

950:

1000:

1050:

1090:

GDPILQLLEG | RKGDREAQVF | VRLRRHRAKQ | ASQHALRPAP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:201294

SMR:

Q70J99

UniGene:

Hs.41045

String:

Q70J99

STRING:

9606.ENSP00000207549

Pfam:

PF00168

MIM:

608897

Uniprot:

Q70J99

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ELISA Kit for Human Protein unc-13 homolog D

Cat.:

E4438r

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96T

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ELISA Kit for Human Protein unc-13 homolog D

Cat.:

E4438h

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MSDS:

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Packing:

96T

ELISA Kit for Human Protein unc-13 homolog D

Cat.:

E4438m

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Packing:

96T

CLIA Kit for Human Protein unc-13 homolog D

Cat.:

U4438r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Protein unc-13 homolog D

Cat.:

U4438h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Protein unc-13 homolog D

Cat.:

U4438m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Protein unc-13 homolog D

Cat.:

P4438Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein unc-13 homolog D

Cat.:

P4438Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein unc-13 homolog D

Cat.:

P4438Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Protein unc-13 homolog D

Protein for Human Protein unc-13 homolog D

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)."
Feldmann J. , Callebaut I. , Raposo G. , Certain S. , Bacq D. , Dumont C. , Lambert N. , Ouachee-Chardin M. , Chedville G. , Tamary H. , Minard-Colin V. , Vilmer E. , Blanche S. , Le Deist F. , Fischer A. , de Saint Basile G.
Cell115:461-473(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INVOLVEMENT IN FHL3
tissue: Blood.
2.

"Characterization of long cDNA clones from human adult spleen."
Hattori A. , Okumura K. , Nagase T. , Kikuno R. , Hirosawa M. , Ohara O.
DNA Res.7:357-366(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Spleen.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Synovium.
4.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Pancreas.
6.

"Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells."
Neeft M. , Wieffer M. , de Jong A.S. , Negroiu G. , Metz C.H. , van Loon A. , Griffith J. , Krijgsveld J. , Wulffraat N. , Koch H. , Heck A.J.R. , Brose N. , Kleijmeer M. , van der Sluijs P.
Mol. Biol. Cell16:731-741(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH RAB27A;TISSUE SPECIFICITY;DOMAIN;MUTAGENESIS OF 608-VAL--ALA-611
7.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4."
Menager M.M. , Menasche G. , Romao M. , Knapnougel P. , Ho C.-H. , Garfa M. , Raposo G. , Feldmann J. , Fischer A. , de Saint Basile G.
Nat. Immunol.8:257-267(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH RAB27A;DOMAIN
10.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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